Aerosolized plus intravenous polymyxin B in comparison to intravenous polymyxin B alone for the management of HAP caused by carbapenem-resistant gram-negative bacteria: A prospective multicenter cohort study
In patients with CRO pneumonia, combination therapy resulted in significant reductions in APACHE II scores and procalcitonin, but did not lead to statistically significant improvements in clinical outcomes, compared to IV polymyxin B alone.
Authors
- Xiaochuang Wang (ORCID: https://orcid.org/0000-0002-4281-5756)
- Linyun Du
- Qindong Shi
- Yanli Hou (ORCID: https://orcid.org/0000-0002-3989-7666)
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0003-2100-3596)
- Jianying Li (ORCID: https://orcid.org/0009-0006-2600-9603)
- Enxia Dong
- Gang Wang (ORCID: https://orcid.org/0000-0002-5048-6606)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-1041-793X)
- Hao Guo (ORCID: https://orcid.org/0000-0001-9463-3500)
- Xuting Jin (ORCID: https://orcid.org/0000-0002-1798-0880)
- Jiamei Li (ORCID: https://orcid.org/0000-0002-4946-2092)
- Xinyu Li (ORCID: https://orcid.org/0000-0002-1270-1053)
Institutions
- Xi'an Honghui Hospital (CN)
- Xi'an Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xian Yang Central Hospital (CN)
- Xi'an Chest Hospital (CN)
- Xiang Yang No.1 People's Hospital (CN)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.ijantimicag.2024.107427
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- National Natural Science Foundation of China