Generation of an induced pluripotent stem cell line from a Kennedy Disease patient with AR mutation
A human induced pluripotent stem cell (iPSC) line was generated from patient with Kennedy Disease (KD), who carried the CAG repeat expansion mutation in AR gene. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using non-integrating delivery of KFL4, OCT4, SOX2, BCL-XL and c-MYC. The iPSC line expresses pluripotency markers, displays a normal karyotype, and is capable of differentiate into three germ layers in vitro. This iPSC line represents a valuable cell model for studing KD in humans.
Authors
- Chuan‐Huan Zhang
- Pengpeng Sun (ORCID: https://orcid.org/0000-0002-8106-5978)
- Rui Liu (ORCID: https://orcid.org/0009-0009-0573-9828)
- Changjiang Li (ORCID: https://orcid.org/0000-0003-4176-3082)
- Jingdong Wang
- Meng Zhang (ORCID: https://orcid.org/0009-0004-5279-5164)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.scr.2024.103649
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao Key Health Discipline Development Fund