Sorafenib Promotes Treg Cell Differentiation To Compromise Its Efficacy via VEGFR/AKT/Foxo1 Signaling in Hepatocellular Carcinoma
Sora induced Treg cell differentiation by inhibiting VEGFR/AKT signaling and activating Foxo1, thus suppressing the immune response and reducing Sora efficacy. Treg inactivation might be a promising strategy to alleviate the immunosuppressive TME and overcome Sora resistance.
Authors
- Zeyu Ma
- Shuowang Wang
- Hanliang Wang
- Yue Fang (ORCID: https://orcid.org/0009-0006-1704-2292)
- Yingying Shen (ORCID: https://orcid.org/0000-0001-8492-0848)
- Changrong Wang (ORCID: https://orcid.org/0000-0001-8745-319X)
- Jufeng Guo (ORCID: https://orcid.org/0000-0001-5341-0271)
- Ying‐Ying Huang (ORCID: https://orcid.org/0000-0003-3066-6981)
- Pingting Ying
- Hongchuan Jin (ORCID: https://orcid.org/0000-0002-6697-3097)
- Xian Wang (ORCID: https://orcid.org/0000-0003-0041-7589)
- Junwei Li (ORCID: https://orcid.org/0009-0000-0919-2289)
- Jia Zhou (ORCID: https://orcid.org/0000-0001-9292-3838)
- Lei Yu (ORCID: https://orcid.org/0000-0002-3504-4893)
- Zhijian Cai
- Jingjing Xiang (ORCID: https://orcid.org/0000-0002-2195-9726)
- Minyan Hao
- Jianli Wang
Institutions
- Sir Run Run Shaw Hospital (CN)
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101454
- Citations
- 10
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China
- Zhejiang Province Public Welfare Technology Application Research Project