Eicosapentaenoic acid enhances intestinal stem cell-mediated colonic epithelial regeneration by activating the LSD1-WNT signaling pathway
These findings demonstrate that EPA promotes ISC proliferation and differentiation, thereby enhancing colonic epithelial regeneration through the activation of LSD1-WNT signaling. Consequently, dietary supplementation with EPA represents a promising alternative therapeutic strategy for managing IBD.
Authors
- Yanling Kuang
- Shaokui Chen
- Wenshuai Xie
- Ding Wang (ORCID: https://orcid.org/0000-0003-4609-9176)
- Pei Li (ORCID: https://orcid.org/0000-0003-2048-405X)
- Xiaojuan Zhang (ORCID: https://orcid.org/0000-0002-1820-9393)
- Dan Wang (ORCID: https://orcid.org/0000-0001-9079-2360)
- Shidong Li (ORCID: https://orcid.org/0000-0003-0517-1215)
- Nayiyuan Wu (ORCID: https://orcid.org/0000-0001-5242-3206)
Institutions
- Wuhan Polytechnic University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.jare.2024.12.050
- Citations
- 32
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 17.61
Funders
- National Natural Science Foundation of China