Gastrointestinal Perforations Associated With JAK Inhibitors: A Disproportionality Analysis of the FDA Adverse Event Reporting System
In this global pharmacovigilance study, all JAK inhibitors were associated with increased reporting of gastrointestinal perforations compared with bDMARDs in RA patients. Until more data on IBD patients emerge, careful surveillance and increased clinicians' awareness should also be advocated for this population.
Authors
- Adi Lahat (ORCID: https://orcid.org/0000-0003-1513-7280)
- Adam Goldman (ORCID: https://orcid.org/0000-0001-5035-100X)
- Ilan Ben‐Zvi (ORCID: https://orcid.org/0000-0002-9160-3098)
- Shomron Ben‐Horin (ORCID: https://orcid.org/0000-0002-3984-4580)
- Emanuel Raschi (ORCID: https://orcid.org/0000-0003-0487-7996)
- Amit Druyan
- Κassem Sharif (ORCID: https://orcid.org/0000-0003-3905-3313)
Institutions
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- University of Bologna (IT)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1002/ueg2.12736
- Citations
- 7
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.45