Geniposide alleviates post-myocardial infarction-induced pyroptosis by modulating the thioredoxin-interacting protein/NLRP3 signaling pathway
GP greatly diminishes the extent of infarcted myocardial tissue and mitigates pyroptosis, which improves cardiac structure and function through modulation of the TXNIP/NLRP3 pathway. Furthermore, the inhibition of NLRP3 lowers the expressions of factors associated with pyroptosis in the cardiac tissue and reduces ROS production.
Authors
- Weiwei Jiang (ORCID: https://orcid.org/0000-0001-7335-5038)
- Suwei Yao (ORCID: https://orcid.org/0000-0001-6336-8126)
- Guanglei Chang
- Chen Li (ORCID: https://orcid.org/0000-0002-6050-4775)
- Ya Liu (ORCID: https://orcid.org/0000-0002-7816-684X)
- Wei Yang (ORCID: https://orcid.org/0000-0002-7083-7872)
- Honghong He (ORCID: https://orcid.org/0000-0002-5209-1800)
- Youqin Jiang
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2024-12-30
- DOI
- https://doi.org/10.25259/cytojournal_139_2024
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment