Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells
Our work presents the first spatially resolved transcriptomic landscape of murine jawbone tissues and uncovers DNA methylation as a crucial mechanism underlying TGF-β1-induced PDLSC senescence. These findings illuminate a previously unrecognized link between TGF-β1 signaling, ROS production, and epigenetic regulation, offering promising avenues for developing stem cell-based therapies to attenuate age-related periodontal diseases and improve systemic health.
Authors
- Yi Fan
- Takehito Ouchi (ORCID: https://orcid.org/0000-0003-4258-2152)
- Zhijie Weng
- Zhihe Zhao (ORCID: https://orcid.org/0000-0003-2955-1706)
- Yafei Chen
- Yueqi Liao
- Longjiang Li (ORCID: https://orcid.org/0000-0003-1446-0692)
- Bo Li (ORCID: https://orcid.org/0000-0002-2820-9098)
- Wei Li (ORCID: https://orcid.org/0000-0002-8627-1578)
Institutions
- Tokyo Dental College (JP)
- Chengdu Medical College (CN)
- Sichuan University (CN)
- National Clinical Research (US)
- Stomatology Hospital (CN)
- State Key Laboratory of Oral Diseases
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.jare.2024.12.037
- Citations
- 16
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 7.01
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan University
- Sichuan Province Science and Technology Support Program
- West China Hospital, Sichuan University