Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children
This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children.
Authors
- Shoko Ono (ORCID: https://orcid.org/0000-0002-4485-6367)
- Sayaka Horiuchi (ORCID: https://orcid.org/0000-0001-5050-8732)
- Anna Kobayashi (ORCID: https://orcid.org/0009-0007-1425-1248)
- Kyoichiro Tsuchiya (ORCID: https://orcid.org/0000-0002-2863-4561)
- Hiroshi Yokomichi (ORCID: https://orcid.org/0000-0001-7369-155X)
- Kenji Kashiwagi (ORCID: https://orcid.org/0000-0001-8506-8503)
- Takeshi Inukai (ORCID: https://orcid.org/0000-0002-4783-2184)
- Tadao Ooka (ORCID: https://orcid.org/0000-0002-1343-3986)
- Daisuke Watanabe (ORCID: https://orcid.org/0000-0002-6526-829X)
- Daiju Sakurai (ORCID: https://orcid.org/0000-0002-5264-8760)
- Masanori Wako (ORCID: https://orcid.org/0000-0001-6311-7909)
- Koichiro Ueki
- Hideki Yui (ORCID: https://orcid.org/0000-0002-8114-887X)
- Takahiko Mitsui (ORCID: https://orcid.org/0000-0003-0408-3678)
- Sanae Otawa
- Kunio Miyake (ORCID: https://orcid.org/0000-0001-9196-2229)
- Hirotaka Haro (ORCID: https://orcid.org/0000-0002-5630-9600)
- Yuka Akiyama (ORCID: https://orcid.org/0000-0002-2928-8533)
- Megumi Kushima
- Reiji Kojima (ORCID: https://orcid.org/0000-0002-9712-889X)
- Ryoji Shinohara (ORCID: https://orcid.org/0000-0003-1791-4119)
Institutions
- University of Yamanashi Hospital (JP)
- University of Yamanashi (JP)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1038/s41598-024-83471-8
- Citations
- 1
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.38
Funders
- Ministry of Education, Culture, Sports, Science and Technology