Reduced irradiation exposure areas enhanced anti-tumor effect by inducing DNA damage and preserving lymphocytes
Our findings suggested that appropriately narrowing the irradiation target volume effectively killed tumor cells while reducing damage to surrounding tissues, and preserving peritumoral lymphocytes. This approach improved the safety of radiotherapy while maintaining its efficacy in tumor control and provided an opportunity for combining high-dose radiotherapy with immunotherapy.
Authors
- Huiqin Chen (ORCID: https://orcid.org/0000-0002-7028-7858)
- Xueqing Yan (ORCID: https://orcid.org/0000-0002-2437-6577)
- Min Wu (ORCID: https://orcid.org/0000-0002-3956-0107)
- Zhigang Wang (ORCID: https://orcid.org/0000-0002-1575-7685)
- Yuan Li (ORCID: https://orcid.org/0000-0001-9996-3197)
- Hanyu Pan
- Gen Yang
- Qiaofeng Shen
- Guanqun Guo
Institutions
- Peking University (CN)
- Wenzhou Medical University (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Nuclear Physics and Technology
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s10020-024-01037-w
- Citations
- 8
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 3.23
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- University of Chinese Academy of Sciences
- National Key Research and Development Program of China
- Wenzhou Institute of Biomaterials and Engineering
- State Key Laboratory of Nuclear Physics and Technology, Peking University
- Nuclear Physics