In Situ Detection of Programmed Cell Death Protein 1 and Programmed Death Ligand 1 Interactions as a Functional Predictor for Response to Immune Checkpoint Inhibition in NSCLC
Our study proposes a diagnostic shift from static biomarker quantification to assessing active immune pathways, providing more precise ICI treatment. This functional concept applies to tiny lung biopsies and can be extended to further immune checkpoints. Accordingly, our results indicate concerted ICI resistance mechanisms, highlighting the need for combination diagnostics and therapies.
Authors
- Max Backman (ORCID: https://orcid.org/0000-0002-8804-1012)
- Klas Kärre (ORCID: https://orcid.org/0000-0001-8869-3195)
- J Friedrich
- Erika Broström (ORCID: https://orcid.org/0000-0003-1354-769X)
- Lars Muhl (ORCID: https://orcid.org/0000-0003-0952-0507)
- Cecilia Lindskog (ORCID: https://orcid.org/0000-0001-5611-1015)
- Amanda Lindberg (ORCID: https://orcid.org/0000-0001-8206-5294)
- Artur Mezheyeuski (ORCID: https://orcid.org/0000-0002-4394-2634)
- Hans Brunnström (ORCID: https://orcid.org/0000-0001-7402-138X)
- Patrick Micke (ORCID: https://orcid.org/0000-0003-1210-5961)
- Johanna Sofia Margareta Mattsson (ORCID: https://orcid.org/0000-0002-5294-7808)
- Miklós Gulyás (ORCID: https://orcid.org/0000-0003-4988-6933)
- Neda Hekmati (ORCID: https://orcid.org/0009-0009-4814-869X)
- Carina Strell (ORCID: https://orcid.org/0000-0002-3783-7256)
- Louise Hellberg
- Johan Isaksson (ORCID: https://orcid.org/0000-0001-5787-0072)
- Johan Botling (ORCID: https://orcid.org/0000-0003-2226-3517)
- Rebecca Artursson
- Hui Yu (ORCID: https://orcid.org/0000-0003-2288-4671)
Institutions
- Uppsala University (SE)
- Lund University (SE)
- Karolinska Institutet (SE)
- Vall d'Hebron Institut de Recerca (ES)
- Integrated Cardio Metabolic Centre (SE)
- Vall d'Hebron Hospital Universitari (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Thoracic Oncology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.jtho.2024.12.026
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Trond Mohn stiftelse
- Cancerfonden
- Vetenskapsrådet
- Akademiska Sjukhuset
- Uppsala Universitet