Remimazolam inhibits apoptosis of endothelial and epithelial cells by activating the PI3K/AKT pathway in acute lung injury
This study presents novel findings elucidating the beneficial effect of REM in ALI. This effect can be attributed to REM's ability to inhibit apoptosis by activating of the PI3K/AKT pathway in endothelial and epithelial cells. Additionally, REM targeted TSPO to regulate this pathway in endothelial cells. These results suggested a potential protective role for REM in ALI/ARDS management.
Authors
- Ya Gao (ORCID: https://orcid.org/0000-0002-5094-9842)
- Xi Xu (ORCID: https://orcid.org/0000-0001-8726-5834)
- Xiaochuang Wang (ORCID: https://orcid.org/0000-0002-4281-5756)
- Jiajia Ren (ORCID: https://orcid.org/0000-0002-6416-9804)
- Xiao‐Ming Gao (ORCID: https://orcid.org/0000-0002-8968-3252)
- Guorong Deng (ORCID: https://orcid.org/0000-0001-7095-3331)
- Gang Wang (ORCID: https://orcid.org/0000-0002-5905-7760)
- Ruohan Li (ORCID: https://orcid.org/0009-0000-6520-6446)
- Xuting Jin (ORCID: https://orcid.org/0009-0002-3514-5069)
- Jiamei Li (ORCID: https://orcid.org/0000-0003-2752-5678)
- Chuchu Zhang (ORCID: https://orcid.org/0000-0001-9234-6073)
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.intimp.2024.113949
- Citations
- 13
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 5.52
Funders
- Young Talent Support Program of Shaanxi Province University