Near-Infrared Light-Responsive Cubic Vesicles for Enhanced Blood-Brain Barrier Permeability and Drug Delivery
Delivering therapeutic agents to the central nervous system (CNS) is challenging due to the blood-brain barrier (BBB). This study presents a novel approach utilizing near-infrared (NIR) light-responsive gold-coated cubic vesicles (Auslip) to modulate BBB permeability and enhance drug delivery to glioma cells. Upon NIR activation, Auslip releases encapsulated agents and transiently opens the BBB. The results demonstrate that Auslip increases doxorubicin (DOX) delivery to glioma C6 cells in a co-culture model with human brain microvascular endothelial cells (hCMEC/D3). This approach offers a promising strategy for CNS therapeutics by enabling simultaneous BBB opening and drug release through optical stimulation.
Authors
- Xiaorong Zheng (ORCID: https://orcid.org/0000-0001-9654-8860)
- Jianwei Jiang (ORCID: https://orcid.org/0000-0002-0071-413X)
- J. Li (ORCID: https://orcid.org/0000-0001-7358-3372)
- Changming Shen
- Hongyan Zhang (ORCID: https://orcid.org/0000-0002-8092-2691)
- Xinyu Wang (ORCID: https://orcid.org/0000-0001-7549-2845)
Institutions
- Zhejiang Chinese Medical University (CN)
- Chinese Academy of Sciences (CN)
- Zhejiang Cancer Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Clinical and Nursing Research
- Published
- 2024-12-31
- DOI
- https://doi.org/10.26689/jcnr.v8i12.9076
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00