Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma
Together, these findings indicate the existence of a molecular context linking dedifferentiation and IFNγ signaling in melanoma which may lead to immune evasion. Additionally, the variability in PD-L1 expression among MITF<sup>low</sup> and MITF<sup>high</sup> cells suggests that high IFNγ-induced PD-L1 expression associates with enhanced inflammatory gene expression. These results imply that modulating melanoma differentiation may help shape IFNγ responsiveness.
Authors
- Berglind O. Einarsdottir (ORCID: https://orcid.org/0000-0002-5227-8149)
- Siggeir F. Brynjólfsson (ORCID: https://orcid.org/0000-0003-0451-5581)
- Oscar F. Sánchez (ORCID: https://orcid.org/0000-0003-2237-0945)
- Adrián López García de Lomana (ORCID: https://orcid.org/0000-0002-9748-347X)
- Eirı́kur Steingrı́msson (ORCID: https://orcid.org/0000-0001-5826-7486)
- Gunnar B. Ragnarsson
- Teitur Sævarsson (ORCID: https://orcid.org/0009-0006-9828-8859)
- Veerle van Esch
Institutions
- University of Iceland (IS)
- National University Hospital of Iceland (IS)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12964-024-01963-6
- Citations
- 8
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.92