Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration
Our study suggests that TR-mediated, T3-induced gene regulation changed the permissive environment during the initial period of regeneration and affected the subsequent patterning/outgrowth period of the regeneration process. Specifically, T3 signaling via TRs inhibits the expression of ECM-related genes while promoting the expression of inflammation-related genes during the blastema formation period. Interestingly, our findings indicate that amputation-induced changes in DNA replication-related pathways can occur during this nonregenerative period. Further studies, particularly on the regenerative microenvironment that may depend on ECM-receptor interaction and cytokine-cytokine receptor interaction, should provide important insights on the regulation of regenerative capacity during vertebrate development.
Authors
- Shouhong Wang (ORCID: https://orcid.org/0000-0002-4634-8833)
- Yun‐Bo Shi (ORCID: https://orcid.org/0000-0002-6330-0639)
- Jianping Jiang (ORCID: https://orcid.org/0000-0002-1051-7797)
- Bin Wang (ORCID: https://orcid.org/0000-0001-6036-5579)
- Liezhen Fu
- Yanmei Cai (ORCID: https://orcid.org/0000-0002-0592-3766)
Institutions
- National Institutes of Health (US)
- Chinese Academy of Sciences (CN)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Chengdu Institute of Biology (CN)
- Sichuan Normal University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12864-024-11175-4
- Citations
- 3
- Primary Topic
- Animal Genetics and Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province
- National Institutes of Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development