Temporal trends, gender, and ethnoracial disparities in mortality from pulmonary emphysema: A retrospective nationwide analysis

Emphysema, a significant global health issue, involves abnormal lung enlargement and wall destruction, affecting 9% to 12% of people worldwide. In the United States (US), 2 million people live with emphysema, with numbers expected to rise. Data on mortality trends and disparities associated with demographic factors is limited, underscoring our study's focus on analyzing these patterns in US adults. This study examined death certificates from the CDC WONDER database for individuals aged 25 and older who died with emphysema (J43) between 1999 and 2020. Age-adjusted mortality rates (AAMRs) and annual percent change were calculated by year, gender, age group, race/ethnicity, geographic region, and urbanization status. Between 1999 and 2020, there were 484,095 reported deaths among emphysema patients. The overall AAMR decreased from 18.5 to 7.2 per 100,000 population, with an annual decrease of 8% from 2008 to 2015, followed by a slight recent increase. Analyzing by age groups, older adults had the highest AAMR of 42. Men had significantly higher AAMRs than women (13.4 vs 7.8). By race, non-Hispanic (NH) White patients had the highest AAMRs (11.3), followed by NH American Indian or Alaska Native (8.2), NH Black (7.7), Hispanic (3.9), and NH Asian or Pacific Islander patients (3.1). Nonmetropolitan areas had higher AAMRs compared to metropolitan areas (11.7 vs 9.8). Emphysema mortality has decreased overall but recently increased slightly. Higher rates are seen among older adults, men, NH White patients, and nonmetropolitan residents. Policies are needed to continue reducing these death rates and to address these disparities.