Tuina alleviates the muscle atrophy induced by sciatic nerve injury in rats through regulation of PI3K/Akt signaling
Tuina could effectively inhibit skeletal muscle atrophy via the microcirculation pathway in a rat model of SNI by regulating the expression of IGF-1 and FoxO. The underlying mechanism of action may involve the PI3K/Akt signaling pathway.
Authors
- Jinping Chen (ORCID: https://orcid.org/0000-0002-0808-6617)
- Hongzheng Zhang (ORCID: https://orcid.org/0000-0001-8105-2256)
- Hourong Wang (ORCID: https://orcid.org/0000-0001-6354-0918)
- Yingqi Zhang (ORCID: https://orcid.org/0000-0001-7783-8336)
- Jiawei Sun (ORCID: https://orcid.org/0009-0000-4532-9174)
- Jun Yan (ORCID: https://orcid.org/0000-0002-7141-4687)
- Hanyu Zhang (ORCID: https://orcid.org/0000-0001-7200-9715)
- Jiayue Liu (ORCID: https://orcid.org/0000-0001-9294-7493)
- Yue Xu (ORCID: https://orcid.org/0009-0009-4955-135X)
- Narentuya shi
- Tianyuan Yu (ORCID: https://orcid.org/0000-0003-2089-3101)
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s13018-024-05270-1
- Citations
- 6
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Beijing Jiaotong University
- Beijing Municipal Natural Science Foundation