N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1
Our findings suggest that the m6A modification of GLIS1, activated by METTL3 and reduced in a YTHDF1-dependent manner, leads to kidney aging by regulating the metabolic shift from FAO to glycolysis. This mechanism provides a promising therapeutic target for kidney aging.
Authors
- Qiuling Fan (ORCID: https://orcid.org/0000-0003-2598-6075)
- Shuo Chen (ORCID: https://orcid.org/0000-0002-5122-3656)
- Xu Li (ORCID: https://orcid.org/0000-0002-6641-6952)
- Fan Liu (ORCID: https://orcid.org/0000-0002-3536-116X)
- Ying Chen (ORCID: https://orcid.org/0009-0005-8351-6620)
- Jiao Wang (ORCID: https://orcid.org/0000-0001-6059-9279)
- Hongyuan Yu (ORCID: https://orcid.org/0000-0003-2106-0304)
- Yonghong Zhu
- Hang Mei
Institutions
- Guangdong Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Stomatology Hospital (CN)
- Shanghai First People's Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12915-024-02100-y
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China