Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
These data propose that despite the similarity in the cellular mechanism, the uptake and accumulation of eTau Monomers and aggregates in human neurons are regulated by different molecular mediators. Thus, they address the possibility of targeting the pathological spreading of Tau aggregates without disturbing the probable physiological or non-pathogenic transport of Tau Monomers.
Authors
- Pijush Chakraborty (ORCID: https://orcid.org/0000-0003-1749-5225)
- Qilin Tang
- Sigrid C. Schwarz
- Negar Mirzazadeh Dizaji
- Daniel Rüdiger (ORCID: https://orcid.org/0000-0002-7817-1884)
- Duncan Stewart Sutherland (ORCID: https://orcid.org/0000-0002-5045-9915)
- Benjamin J. Tuck (ORCID: https://orcid.org/0000-0002-8148-542X)
- Wolfgang Wurst (ORCID: https://orcid.org/0000-0003-4422-7410)
- Brigitte Nuscher (ORCID: https://orcid.org/0009-0000-4661-0742)
- Markus Zweckstetter (ORCID: https://orcid.org/0000-0002-2536-6581)
- Sophie Keeling (ORCID: https://orcid.org/0000-0002-6413-2550)
- Amir Tayaranian Marvian (ORCID: https://orcid.org/0000-0003-1266-2370)
- Thomas Köglsperger
- William A. McEwan (ORCID: https://orcid.org/0000-0002-4408-0407)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Stefan F. Lichtenthaler (ORCID: https://orcid.org/0000-0003-2211-2575)
- Stefan Zahler (ORCID: https://orcid.org/0000-0002-5140-7287)
- Tabea Strauß
- Hossein Mohammad‐Beigi (ORCID: https://orcid.org/0000-0003-2303-795X)
Institutions
- Aarhus University (DK)
- University of Cambridge (GB)
- German Center for Neurodegenerative Diseases (DE)
- TUM Klinikum (DE)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- International Neuroscience Institute (DE)
- Kliniken des Bezirks Oberbayern (DE)
- Munich Cluster for Systems Neurology (DE)
- UK Dementia Research Institute (GB)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s13024-024-00786-w
- Citations
- 9
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.94