Investigation of Cytotoxic Activity of Anthriscus nemorosa (M.Bieb.) Spreng. on Lung Cancer Cells

Medicinal plants are considered an important source of human health due to their therapeutic potential against various diseases including cancer. Cancer is a life-threatening disease characterized by uncontrolled cell growth and abnormal signaling processes. The incidence of cancer in society is increasing day by day. The search for active biological resources is important for the discovery of new anticancer drugs. Anthriscus nemorosa (M.Bieb.) Spreng. (Apiaceae) is a medicinal plant naturally distributed in Turkiye and traditionally used as food and against various diseases. This study investigated the methanol extracts of aerial parts and roots of A. nemorosa for cytotoxicity on lung cancer (A549) and non-cancerous (L929) cell lines. According to the results, both extracts showed significant dose-dependent cytotoxic effects on lung cancer cells. IC50 value was recorded as 8.29 μg/mL in the aerial parts extract. On the other hand, it was recorded as 3.57 μg/mL in the roots extract. Furthermore, the selectivity indexes were calculated as 5.93 and 3.38 for aerial parts and roots extracts, respectively. In light of the findings, it has been concluded that A. nemorosa deserves further anticancer research