Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study
Contrary to our original hypothesis, evidence of BAT assessed by <sup>18</sup>F-FDG-PET-CT imaging at cancer diagnosis was associated with greater body weight maintenance and lower risk for developing cancer cachexia up to one year after diagnosis. Larger, prospective studies and mechanistic experiments are needed to expand and identify the causal factors of our observations.
Authors
- Grigorios Panagiotou (ORCID: https://orcid.org/0000-0003-0690-1478)
- Aaron S. Rosenberg (ORCID: https://orcid.org/0000-0003-0714-734X)
- Ramsey Derek Badawi (ORCID: https://orcid.org/0000-0002-9769-0292)
- Dario F. Mazza
- Soheila Azghadi (ORCID: https://orcid.org/0000-0003-1102-6882)
- Demsina Babazadeh (ORCID: https://orcid.org/0009-0002-1685-0360)
- Nita G. Forouhi (ORCID: https://orcid.org/0000-0002-5041-248X)
- Yasser G. Abdelhafez (ORCID: https://orcid.org/0000-0002-1989-3094)
- Maria Chondronikola (ORCID: https://orcid.org/0000-0002-7762-065X)
- Fumiaki Imamura (ORCID: https://orcid.org/0000-0002-6841-8396)
- Joseph Cawood
- Abhijit J. Chaudhari
Institutions
- University of Cambridge (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- MRC Epidemiology Unit (GB)
- University of California, Davis (US)
Publication Details
- Journal
- Clinical Nutrition
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.clnu.2024.12.028
- Citations
- 13
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- National Institute of Food and Agriculture
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre