Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma
Our results revealed that TM4SF1 regulated tumor cell senescence and immune evasion through the AKT pathway, highlighting its potential as a therapeutic target in HCC, particularly in combination with first-line immunotherapy.
Authors
- Weifeng Zeng (ORCID: https://orcid.org/0000-0001-7161-7145)
- Ze Zhang (ORCID: https://orcid.org/0000-0001-6164-7930)
- Shangwu Ning
- Furong Liu (ORCID: https://orcid.org/0000-0002-1142-5966)
- Yachong Liu (ORCID: https://orcid.org/0000-0003-1895-9837)
- Zhanguo Zhang (ORCID: https://orcid.org/0000-0002-4527-4975)
- Hongwei Zhang (ORCID: https://orcid.org/0000-0002-5954-2061)
- Xiaoping Chen (ORCID: https://orcid.org/0000-0002-5249-1652)
- Zhibin Liao (ORCID: https://orcid.org/0000-0001-9965-4511)
- Haofan Hu
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Saudi Center for Organ Transplantation (SA)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.3350/cmh.2024.0934
- Citations
- 12
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Huazhong University of Science and Technology
- Natural Science Foundation of Hubei Province
- Tongji University
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund
- Tongji Medical College, Huazhong University of Science and Technology