HSPA5-mediated glioma hypoxia tolerance promotes M2 macrophage polarization under hypoxic microenvironment
These observations suggest that HSPA5 upregulation promotes glioma progression by inducing hypoxia tolerance and reshaping the Immunosuppressive phenotype of TAMs. Therefore, targeting HSPA5 may be a novel therapeutic strategy for glioma.
Authors
- Quan Yang (ORCID: https://orcid.org/0000-0001-8590-6984)
- Yang He (ORCID: https://orcid.org/0000-0003-0163-4307)
- Teng Yang (ORCID: https://orcid.org/0009-0000-4542-3814)
- Jixuan Li
- Tao Yan (ORCID: https://orcid.org/0000-0002-2464-2361)
- Mei Zhao (ORCID: https://orcid.org/0000-0003-2600-8126)
- Jiayi Xu (ORCID: https://orcid.org/0009-0006-7929-1446)
- Xin Chen (ORCID: https://orcid.org/0000-0003-4019-552X)
- Yanpeng Xue (ORCID: https://orcid.org/0000-0001-5507-9041)
- Lixian Li (ORCID: https://orcid.org/0000-0003-4353-2229)
- Qingqing Tian
- Qing Jiang
- X. Wei
- Mingdong Du
Institutions
- Harbin Medical University (CN)
- Linyi People's Hospital (CN)
- Sanya Central Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.intimp.2024.113856
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.72