Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation
Our findings highlight the critical role of the deubiquitinase USP39, suggesting that the USP39/ZEB1 axis could serve as a potential diagnostic marker and therapeutic target in MM.
Authors
- Saharnaz Sarlak (ORCID: https://orcid.org/0000-0001-6949-3753)
- Frédéric Luciano (ORCID: https://orcid.org/0000-0001-9253-4998)
- Victoria J. Nicolini (ORCID: https://orcid.org/0000-0001-9192-6391)
- Marcel Deckert (ORCID: https://orcid.org/0000-0003-2094-559X)
- Christophe Bontoux (ORCID: https://orcid.org/0000-0001-5446-6197)
- Patrick Brest (ORCID: https://orcid.org/0000-0002-1252-4747)
- Maeva Dufies
- Sandy Giuliano (ORCID: https://orcid.org/0000-0001-7580-0326)
- Alexandrine Carminati
- Mickaël Ohanna (ORCID: https://orcid.org/0000-0002-7751-9164)
- Manon Teisseire (ORCID: https://orcid.org/0000-0002-0035-0532)
- Jessy Sirera
- Coline Savy
- Gilles Pagès
- Thierry Juel
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Centre Méditerranéen de Médecine Moléculaire (FR)
- Institut de Recherche sur le Cancer et le Vieillissement de Nice (FR)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s13046-024-03241-2
- Citations
- 3
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Ligue Contre le Cancer
- Fondation de France
- Canceropôle PACA