Effect of Triheptanoin on Caudate Atrophy and Motor Scores in Patients With Early-Stage Huntington Disease
This study provides Class I evidence that triheptanoin does not slow caudate atrophy compared with placebo over 6 months in patients with early HD.
Authors
- Mariana Atencio
- Fleur Veldkamp
- Camille Giron
- Alexandra Dürr (ORCID: https://orcid.org/0000-0002-8921-7104)
- Marie-Pierre Luton
- Élodie Hainque (ORCID: https://orcid.org/0000-0001-9049-6246)
- Fanny Mochel (ORCID: https://orcid.org/0000-0003-3970-3486)
- Isaac Adanyeguh (ORCID: https://orcid.org/0000-0003-1402-5877)
- Chris Ottolenghi (ORCID: https://orcid.org/0000-0002-0734-344X)
- Kasper F. van der Zwaan (ORCID: https://orcid.org/0000-0002-5532-5553)
- Abdourahmane Diallo (ORCID: https://orcid.org/0000-0002-2310-4035)
- Emma M. Coppen (ORCID: https://orcid.org/0000-0003-3273-3017)
- Aurélie Méneret (ORCID: https://orcid.org/0000-0002-7623-1142)
- Milou Jacobs (ORCID: https://orcid.org/0000-0002-8846-6678)
- Éric Vicaut (ORCID: https://orcid.org/0000-0001-6303-8557)
- Raymund A.C. Roos (ORCID: https://orcid.org/0000-0001-5591-1133)
- Magali Barbier
- Rabab Debs (ORCID: https://orcid.org/0009-0003-9921-6150)
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Minnesota (US)
- Inserm (FR)
- Université Paris Cité (FR)
- Leiden University Medical Center (NL)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Fernand-Widal (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- Institut du Cerveau (FR)
- Resonance Research (United States) (US)
- Institut des Maladies Génétiques Imagine (FR)
Publication Details
- Journal
- Neurology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1212/wnl.0000000000210194
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Biogen
- Ultragenyx Pharmaceutical
- Agence Nationale de la Recherche
- Servier
- National Institutes of Health