The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status
Differences in the plasma NMR metabolomic profiles are apparent in children with sJIA, but not other JIA subtypes, relative to non-JIA controls. These findings suggest a potential utility for classifying and monitoring JIA through metabolomic profiling, with chronic inflammation, measured by GlycA, potentially playing a role in at least some of these metabolomic differences.
Authors
- Melanie R. Neeland (ORCID: https://orcid.org/0000-0001-7301-9982)
- Justine A. Ellis
- Jane Munro (ORCID: https://orcid.org/0000-0003-4845-9059)
- Boris Novakovic (ORCID: https://orcid.org/0000-0002-5623-9008)
- Toby Mansell (ORCID: https://orcid.org/0000-0002-1282-6331)
- J. Chan Kwon (ORCID: https://orcid.org/0009-0001-9108-1496)
- Richard Saffery (ORCID: https://orcid.org/0000-0002-9510-4181)
Institutions
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- Northern Health (AU)
- Murdoch Children's Research Institute (AU)
- RMIT University (AU)
Publication Details
- Journal
- Pediatric Rheumatology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s12969-024-01041-8
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- National Health and Medical Research Council