Automated craniofacial biometry with 3D T2w fetal MRI
This is the first automated atlas-based protocol using 3D SVR MRI for fetal craniofacial biometrics, accurately revealing morphological craniofacial differences in a T21 cohort. Future work should focus on improving measurement reliability, larger clinical cohorts, and technical advancements, to enhance prenatal care and phenotypic characterisation.
Authors
- Christina Malamateniou (ORCID: https://orcid.org/0000-0002-2352-8575)
- Reza Razavi (ORCID: https://orcid.org/0000-0003-1065-3008)
- Abi Fukami-Gartner (ORCID: https://orcid.org/0000-0001-6825-9025)
- Jacqueline Matthew (ORCID: https://orcid.org/0000-0003-4754-0322)
- Alexia Egloff (ORCID: https://orcid.org/0000-0002-2005-8328)
- Maria Deprez (ORCID: https://orcid.org/0000-0002-2799-6077)
- Daniel Cromb (ORCID: https://orcid.org/0000-0002-9814-8841)
- Aysha Luis (ORCID: https://orcid.org/0000-0001-5493-099X)
- Alena Uus (ORCID: https://orcid.org/0000-0001-5796-2145)
- Vanessa Kyriakopoulou (ORCID: https://orcid.org/0000-0002-9883-0314)
- Jana Hutter (ORCID: https://orcid.org/0000-0003-3476-3500)
- Jonathan O’Muircheartaigh (ORCID: https://orcid.org/0000-0002-8033-6959)
- Sophie Arulkumaran (ORCID: https://orcid.org/0000-0002-4510-1767)
- Mary Rutherford (ORCID: https://orcid.org/0000-0003-3361-1337)
- Joseph V. Hajnal (ORCID: https://orcid.org/0000-0002-2690-5495)
- Kathleen Colford (ORCID: https://orcid.org/0000-0001-6501-8867)
- Lisa Story (ORCID: https://orcid.org/0000-0001-9328-9592)
- Robert Wright (ORCID: https://orcid.org/0000-0003-0437-7430)
Institutions
- St Thomas' Hospital (GB)
- City, University of London (GB)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Universitätsklinikum Erlangen (DE)
Publication Details
- Journal
- PLOS Digital Health
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1371/journal.pdig.0000663
- Citations
- 3
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- King's College London
- European Commission
- NIHR Maudsley Biomedical Research Centre
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Centre For Medical Engineering, King’s College London