Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma

Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques. Our data indicate there are one or more regions with higher cerebral blood flow in PBZ, which we collectively name the "higher cerebral blood flow interface" (HBI). The HBI exhibited more neovascularization than the "lower cerebral blood flow interfaces" (LBI). The HBI tend to have increased infiltration of macrophages and T lymphocytes infiltration compared with that in LBI. There are more tumor cells in the HBI than in LBI, with substantial differences in the gene expression profiles of these tumor cells. HBI may be the key area of PBZ-targeting therapy after surgical resection.

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Publication Details

Journal
Nature Communications
Published
2024-12-30
DOI
https://doi.org/10.1038/s41467-024-55243-5
Citations
13
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
5.69

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article

Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma

Jiheng Zhang, Xueyan Hu, Jianyang Du, Ying Hu et al.
13 citations
Nature Communications
Glioma Diagnosis and Treatment
5.69
article

Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma

Jiheng Zhang, Xueyan Hu, Jianyang Du, Ying Hu, Shaoshan Hu, Hang Ji, Yan Xu, Xin Gao, Fang Wang, Nan Wang, Zhihui Liu, Lei Xu, Yuyun Xu, Cheng-Yun Yang, Jiaqi Jin, Jiawei Dong, Xiuwei Yan, Hongtao Zhao, Shuai Ma
article en
13 citations

Abstract

Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques. Our data indicate there are one or more regions with higher cerebral blood flow in PBZ, which we collectively name the "higher cerebral blood flow interface" (HBI). The HBI exhibited more neovascularization than the "lower cerebral blood flow interfaces" (LBI). The HBI tend to have increased infiltration of macrophages and T lymphocytes infiltration compared with that in LBI. There are more tumor cells in the HBI than in LBI, with substantial differences in the gene expression profiles of these tumor cells. HBI may be the key area of PBZ-targeting therapy after surgical resection.

Nature CommunicationsVol. 15(1)
Harbin Medical University (CN), Harbin Institute of Technology (CN), Sichuan University (CN), West China Hospital of Sichuan University (CN), Zhejiang Provincial People's Hospital (CN), Second Affiliated Hospital of Harbin Medical University (CN), First Affiliated Hospital of Zhengzhou University (CN), Heilongjiang Institute of Technology (CN), Hangzhou Medical College (CN)
Harbin Medical University, Second Affiliated Hospital of Harbin Medical University
Zero hunger
Openalex Percentile: Top 3%
Glioma Diagnosis and Treatment
5.69
DOIOpen Access PDFOpenAlex
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