Exploring the causal relationship between inflammatory cytokines and myasthenia gravis: A two-way Mendelian randomization study

This study uncovers a new connection between inflammatory cytokines and MG, shedding light on potential factors contributing to the development of the disease. Elevated levels of Eotaxin and IL-2ra are associated with a higher risk of MG, while indicating that MIG, MIP1α, GROa, IL-13, TRAIL, IL-2ra, and IL-1ra may be elevated as a result of MG, Especially MIG. These findings suggest that targeting and regulating specific inflammatory factors could offer promising avenues for the treatment and prevention of MG.

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Publication Details

Journal
Cytokine
Published
2024-12-30
DOI
https://doi.org/10.1016/j.cyto.2024.156843
Citations
1
Primary Topic
Myasthenia Gravis and Thymoma
Type
article
Field-Weighted Citation Impact
0.37
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article

Exploring the causal relationship between inflammatory cytokines and myasthenia gravis: A two-way Mendelian randomization study

Xiaochen Zheng, Wenhui Bao, Yeong Hann Ling, Jingyu Li et al.
1 citations
Cytokine
Myasthenia Gravis and Thymoma
0.37
article

Exploring the causal relationship between inflammatory cytokines and myasthenia gravis: A two-way Mendelian randomization study

Xiaochen Zheng, Wenhui Bao, Yeong Hann Ling, Jingyu Li, Qi Zhao, Wenna Zhang, Xinpeng Han
article en
1 citations

Abstract

This study uncovers a new connection between inflammatory cytokines and MG, shedding light on potential factors contributing to the development of the disease. Elevated levels of Eotaxin and IL-2ra are associated with a higher risk of MG, while indicating that MIG, MIP1α, GROa, IL-13, TRAIL, IL-2ra, and IL-1ra may be elevated as a result of MG, Especially MIG. These findings suggest that targeting and regulating specific inflammatory factors could offer promising avenues for the treatment and prevention of MG.

CytokineVol. 186
Tianjin University of Traditional Chinese Medicine (CN), Sun Yat-sen University (CN), First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
Zero hunger
Openalex Percentile: Top 32%
Myasthenia Gravis and Thymoma
0.37
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