Exploring the causal relationship between inflammatory cytokines and myasthenia gravis: A two-way Mendelian randomization study
This study uncovers a new connection between inflammatory cytokines and MG, shedding light on potential factors contributing to the development of the disease. Elevated levels of Eotaxin and IL-2ra are associated with a higher risk of MG, while indicating that MIG, MIP1α, GROa, IL-13, TRAIL, IL-2ra, and IL-1ra may be elevated as a result of MG, Especially MIG. These findings suggest that targeting and regulating specific inflammatory factors could offer promising avenues for the treatment and prevention of MG.
Authors
- Xiaochen Zheng
- Wenhui Bao
- Yeong Hann Ling
- Jingyu Li (ORCID: https://orcid.org/0000-0002-2511-4157)
- Qi Zhao (ORCID: https://orcid.org/0000-0003-1412-2722)
- Wenna Zhang
- Xinpeng Han
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cytokine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.cyto.2024.156843
- Citations
- 1
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.37