In vivo imaging of glycogen in human muscle

Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial resolution of millimeters and temporal resolution of minutes, using relayed nuclear Overhauser effect (glycoNOE) MRI. Data at 5T showed a homogeneous distribution of glycogen in resting muscle, with an average concentration of 99 ± 13 mM. After plantar flexion exercise following fasting with recovery under fasting conditions, the calf muscle showed spatially heterogeneous glycogen depletion and repletion kinetics that correlated with the severity of this depletion. Three types of regional glycogen kinetics were observed: (i) single exponential repletion (type a); (ii) biphasic recovery of rapid repletion followed by additional depletion (type b); (iii) biphasic recovery where continued depletion is followed by an exponential recovery (type c). The study of the complex patterns of glycogen kinetics suggests that glycogen breakdown may be quantitatively important during the initial recovery.

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Publication Details

Journal
Nature Communications
Published
2024-12-30
DOI
https://doi.org/10.1038/s41467-024-55132-x
Citations
6
Primary Topic
Advanced MRI Techniques and Applications
Type
article
Field-Weighted Citation Impact
2.43

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article

In vivo imaging of glycogen in human muscle

Chao Zou, Nirbhay N. Yadav, Hairong Zheng, Chongxue Bie et al.
6 citations
Nature Communications
Advanced MRI Techniques and Applications
2.43
article

In vivo imaging of glycogen in human muscle

Chao Zou, Nirbhay N. Yadav, Hairong Zheng, Chongxue Bie, Peter C.M. van Zijl, José L. Areta, Yuxuan Ma, Lin Chen, Yang Zhou, Dong Liang, Xi Xu
article en
6 citations

Abstract

Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial resolution of millimeters and temporal resolution of minutes, using relayed nuclear Overhauser effect (glycoNOE) MRI. Data at 5T showed a homogeneous distribution of glycogen in resting muscle, with an average concentration of 99 ± 13 mM. After plantar flexion exercise following fasting with recovery under fasting conditions, the calf muscle showed spatially heterogeneous glycogen depletion and repletion kinetics that correlated with the severity of this depletion. Three types of regional glycogen kinetics were observed: (i) single exponential repletion (type a); (ii) biphasic recovery of rapid repletion followed by additional depletion (type b); (iii) biphasic recovery where continued depletion is followed by an exponential recovery (type c). The study of the complex patterns of glycogen kinetics suggests that glycogen breakdown may be quantitatively important during the initial recovery.

Nature CommunicationsVol. 15(1)
Kennedy Krieger Institute (US), Johns Hopkins University (US), Chinese Academy of Sciences (CN), Johns Hopkins Medicine (US), Shenzhen Institutes of Advanced Technology (CN), Liverpool John Moores University (GB), Xiamen University of Technology (CN)
National Natural Science Foundation of China, National Institutes of Health, National Key Research and Development Program of China
Openalex Percentile: Top 10%
Advanced MRI Techniques and Applications
2.43
DOIOpen Access PDFOpenAlex
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