Alcohol Use Disorder Polygenic Score Compared With Family History and <i>ADH1B</i>
In this study of AUD risk among populations of European ancestry, PGSs were calculated using concordant single-nucleotide variants and the best PGS was tested in targeted datasets. The findings suggest that the PGS may potentially be used to evaluate AUD risk. More datasets with similar AUD prevalence as in general populations are needed to further test the generalizability of PGS.
Authors
- Weipeng Kuang (ORCID: https://orcid.org/0009-0008-2622-2556)
- Danielle M. Dick (ORCID: https://orcid.org/0000-0002-1636-893X)
- Grace Chan (ORCID: https://orcid.org/0000-0002-1257-6889)
- John I. Nürnberger (ORCID: https://orcid.org/0000-0002-7674-1767)
- Tae-Hwi Linus Schwantes-An (ORCID: https://orcid.org/0000-0001-6387-0095)
- Marc A. Schuckit (ORCID: https://orcid.org/0000-0002-2323-7858)
- Dongbing Lai (ORCID: https://orcid.org/0000-0001-7803-580X)
- Chella Kamarajan
- Martin H. Plawecki (ORCID: https://orcid.org/0000-0003-0708-9514)
- Bernice Porjesz (ORCID: https://orcid.org/0000-0003-2489-0389)
- Yunlong Liu (ORCID: https://orcid.org/0000-0002-2699-626X)
- Michael Zhang (ORCID: https://orcid.org/0000-0002-7067-0689)
- John P. Rice (ORCID: https://orcid.org/0000-0002-1462-6958)
- Marco Abreu (ORCID: https://orcid.org/0000-0002-5659-1255)
- Tatiana Foroud
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Iowa (US)
- University of Connecticut (US)
- SUNY Downstate Health Sciences University (US)
- Washington University in St. Louis (US)
- Johnson University (US)
- University of California San Diego Medical Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.52705
- Citations
- 4
- Primary Topic
- Substance Abuse Treatment and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Institutes of Health