Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence
In this cohort study of children, preexisting neuroanatomical variability was associated with substance use initiation. In addition to putative neurotoxic effects of substance exposure, brain structure variability may reflect predispositional risk for initiating substance use earlier in life with potential cascading implications for development of later problems.
Authors
- Hugh P Garavan (ORCID: https://orcid.org/0000-0002-8939-1014)
- Ryan Bogdan (ORCID: https://orcid.org/0000-0002-1430-1045)
- Kimberly H. LeBlanc (ORCID: https://orcid.org/0000-0002-9333-5963)
- Sarah E. Paul (ORCID: https://orcid.org/0000-0003-0320-7907)
- David A. A. Baranger (ORCID: https://orcid.org/0000-0002-6659-357X)
- Scott Mackey (ORCID: https://orcid.org/0000-0001-7817-7437)
- Susan Frances Tapert (ORCID: https://orcid.org/0000-0001-7259-6112)
- Alex P. Miller (ORCID: https://orcid.org/0000-0001-9163-8947)
- Arpana Agrawal
Institutions
- University of Vermont (US)
- National Institute on Drug Abuse (US)
- Washington University in St. Louis (US)
- University of California San Diego (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.52027
- Citations
- 28
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 31.06