Investigating residual trace metals in recombinant monoclonal antibodies to facilitate drug development with LC-UV-ICPMS-HRMS
This LC-UV-ICPMS-HRMS method enables deeper understanding of metal-mAb interactions and offers information on both metal and metal-binding molecules in a single experiment, thus saving time and minimizing sample consumption. Consequently, this method can effectively and directly facilitate exploration of metal-mAb interactions during drug development.
Authors
- Hongxia Wang (ORCID: https://orcid.org/0000-0001-6689-9694)
- Jikang Wu (ORCID: https://orcid.org/0000-0003-2888-5659)
- Ning Li (ORCID: https://orcid.org/0000-0001-6750-4308)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-0978-2363)
- Xueqing Zhao (ORCID: https://orcid.org/0000-0003-3515-6008)
- Haibo Qiu (ORCID: https://orcid.org/0000-0002-8449-4233)
Institutions
- Regeneron (United States) (US)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.aca.2024.343595
- Citations
- 2
- Primary Topic
- Protein purification and stability
- Type
- article
- Field-Weighted Citation Impact
- 0.47