Factors affecting the direct red cell effect on thrombosis: Hematocrit dilution and injury patterns
Neither hemoconcentration or age of donated blood products affect the calcium and tissue-factor dependent aggregability of RBCs. Further, RBC aggregation is increased in the presence of plasma, not platelets-indicating a potential role for plasma in regulating RBC aggregation. Finally, injury patterns including TBI and hemorrhagic shock may influence hypercoagulability or coagulopathy via change in RBC aggregability.
Authors
- Taylor E. Wallen (ORCID: https://orcid.org/0000-0003-2671-7168)
- Lisa England
- Ellen R Becker (ORCID: https://orcid.org/0009-0005-6623-4242)
- Adam D Price (ORCID: https://orcid.org/0000-0003-4330-4306)
- Timothy A. Pritts (ORCID: https://orcid.org/0000-0003-2495-3255)
- Matthew R Baucom (ORCID: https://orcid.org/0000-0002-5444-7575)
- Michael D. Goodman (ORCID: https://orcid.org/0000-0001-7218-4855)
- Ryan C Chae (ORCID: https://orcid.org/0000-0002-2045-0303)
- Rebecca Schuster
Institutions
- Sabin Vaccine Institute (US)
- University of Cincinnati (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1097/ta.0000000000004513
- Citations
- 1
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.42