Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023
Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020-2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment.
Authors
- Irina Nastassja Riediger (ORCID: https://orcid.org/0000-0002-4804-0429)
- Thauane Silva (ORCID: https://orcid.org/0000-0002-0427-4637)
- Rejane Schaefer (ORCID: https://orcid.org/0000-0002-3511-0221)
- Luciana Appolinario (ORCID: https://orcid.org/0000-0001-5700-5804)
- Aline da Rocha Matos (ORCID: https://orcid.org/0000-0001-7763-2127)
- Larissa Macedo (ORCID: https://orcid.org/0000-0002-4665-9981)
- Fernando Couto Motta (ORCID: https://orcid.org/0000-0003-4272-4325)
- Ana Carolina Dalla Vecchia (ORCID: https://orcid.org/0009-0009-7988-0437)
- Marilda Mendonça Siqueira (ORCID: https://orcid.org/0000-0003-4685-9817)
- Elisa Cavalcante Pereira (ORCID: https://orcid.org/0000-0003-4866-3682)
- Jonathan Christian Oliveira Lopes
- Paola Cristina Resende (ORCID: https://orcid.org/0000-0002-2884-3662)
- Acácia Maria Lourenço Francisco Nasr (ORCID: https://orcid.org/0000-0002-7663-6094)
- Caroline Tochetto (ORCID: https://orcid.org/0000-0002-9804-6175)
- Walquíria Aparecida Ferreira de Almeida (ORCID: https://orcid.org/0000-0003-2082-6283)
- Maria do Carmo Debur (ORCID: https://orcid.org/0000-0001-5888-859X)
- Dennis Maletich Junqueira (ORCID: https://orcid.org/0000-0003-1576-484X)
- Guilherme Becker (ORCID: https://orcid.org/0000-0001-9678-2980)
- Livia Lima (ORCID: https://orcid.org/0000-0002-1043-2291)
- Bráulia Costa Caetano (ORCID: https://orcid.org/0000-0002-1373-8966)
- Rosana Aparecida Piler (ORCID: https://orcid.org/0000-0001-9386-661X)
- David W. Brown (ORCID: https://orcid.org/0000-0002-2566-0086)
- Maria Ogrzewalska (ORCID: https://orcid.org/0000-0002-9207-743X)
- Aline Andrade (ORCID: https://orcid.org/0000-0003-3781-5409)
Institutions
- Universidade Federal de Santa Maria (BR)
- Ministério da Saúde (BR)
- Secretaria da Saúde (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1038/s41467-024-53815-z
- Citations
- 8
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Ministério da Saúde