Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma
TXNIP is significantly involved in the inflammation-related neuropathy of experimental glaucoma and probably facilitates M1-like microglial transformation via PI3K/Akt pathway.
Authors
- Bingqiao Shen
- Yisheng Zhong (ORCID: https://orcid.org/0000-0001-5604-6591)
- Junjue Chen
- Shouyue Huang (ORCID: https://orcid.org/0000-0002-0698-0527)
- Huan Yu (ORCID: https://orcid.org/0000-0002-7249-1131)
- Huimin Zhong (ORCID: https://orcid.org/0000-0002-1371-6951)
- Ping Huang (ORCID: https://orcid.org/0000-0002-2513-8984)
- Ruiqi Han (ORCID: https://orcid.org/0000-0002-7379-8135)
- Yang Zhang (ORCID: https://orcid.org/0000-0001-7490-8343)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Zhoushan Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s10020-024-01058-5
- Citations
- 7
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Science and Technology Commission of Shanghai Municipality
- Postdoctoral Research Foundation of China
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission