Evaluation of the Anti-Psoriatic Activity of Mangifera Indica Flower Extract in Different Solvents

Mangifera indica (M.indica) is considered to be medicinal plant that belongs to ayurvedic family of plants used against numerous diseases and disorders. The objective of this research is to assess the anti-psoriatic effectiveness M.indica flower extract in various solvents. The current study was designed to formulate an anti-psoriatic spray at Fatima Tul Zahra Department of Life Sciences, Muhammad Institute of Medical & Allied Science, Multan. The M.indica flowers were collected from Multan Mango Farm and M.indica flowers extracts were prepared separately by macerated grinding of fresh flowers using different solvents (n-hexane, ethanol and olive oil) by mortar and pestle that were stored in air tight glass bottles separately for 7days before filtration through double layered muslin cloth. The filtrate (pellets) were obtained from filtered pharmaceutical product through rotary evaporator at 37°C at low pressure to prepare 5%, 10% and 20% (W/V) solutions with same solvents separately that were applied topically using sprayer bottles on psoriasis affected skin area of rabbits to evaluate the therapeutic effects keeping the patients free of any other allopathic medicines for two week. Out of 33 rabbits with mean age 34.62±5.11 years, 27 rabbits were trialed in experimental group (n=27), other than positive control (n=3) and negative control (n=3), while corticosteroid ointment and distilled water were used as standard drug for positive control and negative control groups respectively. Surprisingly in our study, 100% rabbits were recovered from psoriasis treated with olive oil flowers extract that was 33.33% of experimental group. Statistical analysis was done with SPSS version-22, based on obtained data during research trial. Lack of proper treatment and adverse effects of allopathic medicines including anticancer drugs urged the way to find the natural products with anti-psoriatic activity. The present findings suggest that the M.indica flowers extract possesses significant potential in mitigating psoriasis-related symptoms. The diverse solvents used for extraction demonstrated variations in efficacy, emphasizing the importance of solvent selection in extracting bioactive compounds.