Major role of dolutegravir in the emergence of the S147G integrase resistance mutation
In this French study, S147G emerged principally in patients on dolutegravir regimens, in association with up to five other INSTI resistance mutations. This accumulation of mutations suggests a replicative advantage on HIV strains under dolutegravir selection pressure, suggesting that caution is required when interpreting dolutegravir resistance in the presence of such S147G resistance patterns, even in patients prescribed dolutegravir twice daily.
Authors
- Basma Abdi (ORCID: https://orcid.org/0000-0002-9139-0010)
- Sabine Yerly (ORCID: https://orcid.org/0000-0003-1668-696X)
- Vincent Cálvez (ORCID: https://orcid.org/0009-0002-6855-3472)
- Brigitte Montès (ORCID: https://orcid.org/0000-0003-2866-4274)
- Magali Bouvier‐Alias (ORCID: https://orcid.org/0000-0003-1590-5980)
- Anne‐Geneviève Marcelin (ORCID: https://orcid.org/0000-0003-4808-8999)
- Marc Wirden (ORCID: https://orcid.org/0009-0003-3723-4142)
- Sidonie Lambert-Niclot (ORCID: https://orcid.org/0000-0002-3378-250X)
- Charlotte Charpentier (ORCID: https://orcid.org/0000-0002-6441-7054)
- Marie‐Laure Chaix (ORCID: https://orcid.org/0000-0002-7798-4621)
- Stéphanie Raymond (ORCID: https://orcid.org/0000-0002-3780-5844)
- Coralie Pallier
- Diane Descamps
- Anne De Monte
- Pantxika Bellecave
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Hospital of Geneva (CH)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Hôpital Saint-Louis (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Hôpital Paul-Brousse (FR)
- Laboratoire de Microbiologie Fondamentale et Pathogénicité (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/jac/dkae457
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales