Water Extract of Djulis Husk Exerts Protective Effect Against Metabolic Syndrome

Djulis (<i>Chenopodium formosanum</i> Koidz.) possesses various biological activities, including anti-oxidant, anti-hyperglycemic, anti-aging and hepatoprotective properties. Although djulis husk is typically considered agricultural waste, there is value in exploring ways to utilize it effectively. This study aimed to investigate the protective effects of the water extract of djulis husk (WDH) in rats with high-fructose-induced metabolic syndrome. The results showed that WDH significantly ameliorated the metabolic syndrome induced by a high-fructose diet in rats. Supplementation with low-dose WDH (0.5% of diet, w/w) significantly improved metabolic syndrome, including high blood pressure, hypertriglyceridemia, and insulin resistance. The protective effects of WDH against metabolic syndrome may be associated with increased expression of the genes encoding insulin receptor substrates-1 (IRS-1) and glucose transporter 4 (GLUT-4) in the epididymal fat. Thus, WDH is likely a functional food ingredient for the prevention of metabolic syndrome.