Ultrasound-assisted synthesis of α-aminophosphonates using nano ZnO catalyst: evaluation of their anti-diabetic activity

A more efficient and environmentally friendly way of synthesizing -aminophosphonates is achieved by employing nano-ZnO to catalyze the Kabachnik-Fields reaction under ultrasonication within a solvent-free environment.Before synthesis, molecular docking and in silico ADME analysis were used to assess each molecule's drug-like characteristics and ability to inhibit -amylase and -glucosidase.The newly synthesized compounds' in vitro inhibitory effects on -amylase and -glucosidase were also evaluated, and their structure was confirmed using spectroscopic investigation.The target enzyme was effectively inhibited by most of the substances.In comparison to the reference drug, acarbose (IC50, 106.50.6 g/mL), compounds 4d (IC50, 102.20.3 g/mL), 4h (IC50, 102.90.4 g/mL), which contained a 2H-1,3-benzodioxol-5-yl moiety, and 4i (IC50, 103.90.5 g/mL) showed the strongest inhibitory activity.The enzyme inhibition of the remaining compounds ranged from moderate to good.