Genetic Expression of Transient Receptor Potential Channels in Plaque Psoriasis

Aim: Psoriasis is an immune-associated cutaneous condition characterized by inflammation.The transient receptor potential canonical (TRPC), transient receptor potential ankyrin (TRPA), transient receptor potential melastatin (TRPM), transient receptor potential vanilloid (TRPV), transient receptor potential polycystin (TRPP), and transient receptor potential mucolipin (TRPML) families are mammalian transient receptor potential (TRP) channels, and abnormal differentiation or barrier dysfunction may be attributed to their abnormal expression.This study aimed to investigate gene expression in TRP channels in psoriatic cases and to associate the expression level with disease severity.Methods: This research was case-controlled and comprised 60 patients with psoriasis vulgaris and 60 years and sex-coordinated well-health volunteers as the control group.The patient's entire history was recorded, and a general and complete dermatological examination was performed.The disease severity was evaluated by applying the psoriasis area and severity index score.Venous blood samples were taken for the detection of TRPC6, TRPM2, and TRPV1 gene expression by real-time polymerase chain reaction. Results:Considering TRPC6; the mean expression level was lower in patients than in controls, with a statistically significant difference (U = 661.5 and P < 0.001).Nevertheless, TRPM2 and TRPV1 demonstrated higher expression levels in cases than controls (U = 36 and 78, resp., and P < 0.001 for both).Therefore, TRPM2 and TRPV1 can be used to distinguish cases from controls with significant accuracy (P < 0.001 for both). Conclusion:Variations in TRP channel expression patterns may be involved in the etiopathogenesis of psoriasis and may be useful and promising agents for psoriasis treatment.