Epigenetic and Metabolic Landscape of Dementia with Lewy Bodies
Notably, sex-specific differences were found, with females exhibiting more epigenetic and metabolomic changes than males. Increased hypermethylation, linked to transcriptional silencing, and disruptions in PE biosynthesis suggest a role in synaptic dysfunction and olfactory deficits. In addition, α-aminoadipic acid was strongly associated with vascular functions, hinting at a possible overlap between vascular health and DLB. This study provides new insights into DLB mechanisms and potential therapeutic targets. © 2024 International Parkinson and Movement Disorder Society.
Authors
- Brian D. Green (ORCID: https://orcid.org/0000-0003-3331-0032)
- Ali Yılmaz (ORCID: https://orcid.org/0000-0002-7482-1712)
- Ieva Kerševičiūtė
- Patrick G. Kehoe (ORCID: https://orcid.org/0000-0002-7542-1139)
- Uppala Radhakrishna (ORCID: https://orcid.org/0000-0002-6617-5634)
- Sangeetha Vishweswaraiah
- Bernadette McGuinness (ORCID: https://orcid.org/0000-0002-7028-5633)
- Juozas Gordevičius
- Peter Passmore (ORCID: https://orcid.org/0000-0002-5738-6800)
- Stewart Francis Graham (ORCID: https://orcid.org/0000-0003-1001-0002)
- Milda Milčiūtė (ORCID: https://orcid.org/0009-0002-2214-9140)
- Karolis Krinickis
Institutions
- Queen's University Belfast (GB)
- Oakland University (US)
- University of Bristol (GB)
- Pittsburg State University (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1002/mds.30095
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00