Late-stage C–H trifluoroacetylation of quinoxaline-2(1<i>H</i>)-ones using masked trifluoroacyl reagents
A strategy for trifluoroacetylation of quinoxaline-2(1<i>H</i>)-ones has been investigated. This strategy employs masked trifluoroacyl reagents to obtain trifluoroacetylated quinoxaline-2(1<i>H</i>)-ones under metal-, catalyst-, and light-free conditions. This approach is distinguished by its functional group compatibility and tolerance, as well as the simplicity of the experimental process, making it suitable for gram-scale synthesis.
Authors
- Kai Luo (ORCID: https://orcid.org/0000-0002-2525-9866)
- Lei Wu (ORCID: https://orcid.org/0000-0001-9130-6619)
- Yangyang Shen (ORCID: https://orcid.org/0000-0003-4607-9722)
- Xia Wang (ORCID: https://orcid.org/0000-0002-5256-0611)
- Li Yuan (ORCID: https://orcid.org/0000-0003-0244-4871)
- Yawei Shen (ORCID: https://orcid.org/0000-0002-7539-4388)
- Jie Wei
Institutions
- Nanjing Agricultural University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1039/d4ob01945h
- Citations
- 5
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- National Natural Science Foundation of China