Evidence for spinal disinhibition as a pain-generating mechanism in fibromyalgia syndrome
We demonstrate for the first time that people with FMS show evidence of spinal disinhibition, which is most dominant in shorter duration of disease and may represent a putative mechanism of pain generation in FMS. Identifying people with impairment of central pain processing at an early stage may provide opportunities for targeted mechanistically directed interventions. Longitudinal studies are warranted to tease out the precise contribution of these mechanisms.
Authors
- Bernhard Frank (ORCID: https://orcid.org/0000-0001-5405-4942)
- Uazman Alam (ORCID: https://orcid.org/0000-0002-3190-1122)
- Andreas Göebel (ORCID: https://orcid.org/0000-0002-3763-8206)
- Anne Marshall (ORCID: https://orcid.org/0000-0002-2331-3750)
- Andrew G. Marshall (ORCID: https://orcid.org/0000-0001-8273-7089)
- Jamie Burgess (ORCID: https://orcid.org/0000-0002-7165-6918)
Institutions
- Apple (Israel) (IL)
- University of Liverpool (GB)
- University of Staffordshire (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Walton Centre (GB)
Publication Details
- Journal
- PAIN Reports
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1097/pr9.0000000000001236
- Citations
- 3
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Versus Arthritis