Early changes of peripheral circulating immune subsets induced by PD-1 inhibitors in patients with advanced malignant melanoma and non-small cell lung cancer
In summary, our findings suggest that CD4 + TEM and TCM baselines and an early increase in the Treg count induced by PD-1 inhibitors and the proportion of CD28 + ICOS- T cells may be useful in predicting the response in NSCLC and MM patients.
Authors
- Radek Lakomý (ORCID: https://orcid.org/0000-0003-4961-0339)
- Marie Mlnaříková
- Ján Podhorec
- Jiří Nevrlka (ORCID: https://orcid.org/0000-0002-5286-0630)
- Iveta Selingerová (ORCID: https://orcid.org/0000-0003-3713-3504)
- Lenka Zdražilová Dubská (ORCID: https://orcid.org/0000-0001-6397-0993)
- Igor Kišš (ORCID: https://orcid.org/0000-0001-7693-0659)
- Rostislav Vyzula
- Simona Bořilová (ORCID: https://orcid.org/0000-0002-2415-8684)
- Peter Grell (ORCID: https://orcid.org/0000-0001-8241-0609)
- Alexandr Poprach (ORCID: https://orcid.org/0000-0003-4698-9195)
- Lenka Gescheidtová (ORCID: https://orcid.org/0000-0002-3786-2400)
- Ondřej Bílek (ORCID: https://orcid.org/0000-0001-9581-3423)
- Barbora Vavrusakova
Institutions
- Masaryk University (CZ)
- University Hospital Brno (CZ)
- Masaryk Memorial Cancer Institute (CZ)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s12885-024-13351-x
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- European Commission
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Ministerstvo Zdravotnictví Ceské Republiky