CircRNA profiling reveals the regulatory role of circPAN3 in Hezuo boars Sertoli cell growth
This study revealed the dynamic expression profiles and regulatory mechanisms of circRNAs during sexual maturation in HZ pigs. Further functional studies demonstrated that circPAN3 promoted the proliferation and inhibited the apoptosis of immature Sertoli cells, suggesting that circPAN3 may be closely related to the characteristics of precocious puberty in HZ boars. These findings provide a new perspective for exploring the regulatory mechanism of circRNAs in precocious puberty in HZ pigs.
Authors
- Shuangbao Gun (ORCID: https://orcid.org/0000-0001-6242-7550)
- Zunqiang Yan (ORCID: https://orcid.org/0000-0001-8701-0647)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-2509-7342)
- Hong Du (ORCID: https://orcid.org/0009-0009-4843-4899)
- Haixia Shi
Institutions
- Gansu Agricultural University (CN)
- Gansu Academy of Agricultural Sciences (CN)
- Gansu Academy of Machinery Science (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s12864-024-11170-9
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gansu Agricultural University