Dihydroartemisinin Inhibits T Cell Activation in People Living with HIV with Incomplete Immune Reconstitution <i>In Vitro</i>
Incomplete immune reconstitution is characterized by chronic immune activation and systemic inflammation, which are not fully reversed by antiretroviral therapy. Dihydroartemisinin (DHA) has demonstrated anti-inflammatory and immunosuppressive properties, which may benefit individuals with incomplete immune reconstitution. This study aimed to investigate the biological mechanisms underlying incomplete immune reconstitution and evaluate the therapeutic potential of DHA in modulating immune activation in immunological non-responders (INRs). This study aimed to investigate the biological mechanisms underlying incomplete immune reconstitution and evaluate the therapeutic potential of DHA in modulating immune activation in immunological non-responders (INRs).
Authors
- Jiahao Ji (ORCID: https://orcid.org/0009-0006-8431-5465)
- Hao Wu (ORCID: https://orcid.org/0000-0002-1502-1758)
- Xiao Dou (ORCID: https://orcid.org/0009-0007-1558-4001)
- Rui Wang (ORCID: https://orcid.org/0000-0002-3636-1399)
- Zhen Li (ORCID: https://orcid.org/0000-0003-0298-1677)
- Tong Zhang (ORCID: https://orcid.org/0000-0003-2534-4785)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-8632-879X)
Publication Details
- Journal
- Journal of Exploratory Research in Pharmacology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.14218/jerp.2024.00014
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China