Screening and identification of vascular endothelial cell targeting peptide in gastric cancer through novel integrated in vitro and in vivo strategy
Our novel strategy of the combined in vitro and in vivo screening outperforms previous methods that relied solely on negative/positive screening. In vivo and in vitro test confirmed the high targeting characteristic of the new peptide. Therefore, the peptide CNTGSPYEC may be a potential candidate in diagnosis and anti-angiogenesis therapy of gastric cancer. Our further exploration employs it as a vehicle for mediating drug accumulation in gastric cancer tissue.
Authors
- Li Zhao (ORCID: https://orcid.org/0000-0002-3347-6377)
- Huimin Wang (ORCID: https://orcid.org/0000-0002-4692-4917)
- Shuo Liang (ORCID: https://orcid.org/0000-0001-7842-7782)
- Rongrong Shi
- Bei Chen (ORCID: https://orcid.org/0000-0003-2553-3279)
- Lin Wang (ORCID: https://orcid.org/0000-0002-6334-0139)
- Shenghui Wang (ORCID: https://orcid.org/0000-0003-3325-0754)
- Baofeng Li (ORCID: https://orcid.org/0000-0001-8517-2263)
- Yan-ting Zhang
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s12885-024-13375-3
- Citations
- 3
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province