Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds
Both strategies for forming injectable BT seeds containing high <sup>103</sup>Pd activity resulted in high radiolabeling yields, high activity per seed, and high activity retention. We consider both strategies suitable for BT, with the preferable strategy using a [16]aneS<sub>4</sub> chelator due to its higher biodegradability.
Authors
- Jonas R. Henriksen (ORCID: https://orcid.org/0000-0001-9154-6639)
- Thomas L. Andresen (ORCID: https://orcid.org/0000-0002-1048-127X)
- Natan J. W. Straathof (ORCID: https://orcid.org/0000-0003-0293-1530)
- Andreas I. Jensen (ORCID: https://orcid.org/0000-0002-9085-8603)
- Linda M. Bruun (ORCID: https://orcid.org/0000-0002-2617-9606)
- Paul J. Kempen (ORCID: https://orcid.org/0000-0003-2179-2257)
- U. Köster (ORCID: https://orcid.org/0000-0001-5701-3249)
- Claire Deville (ORCID: https://orcid.org/0000-0002-5007-912X)
- Mikael Jensen (ORCID: https://orcid.org/0000-0002-9109-2187)
- Emanuel Sporer
Institutions
- Ørsted (Denmark) (DK)
- Institut Laue-Langevin (FR)
- Technical University of Denmark (DK)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s41181-024-00309-4
- Citations
- 2
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81