Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations
Our study suggests that rare variants are a major source of the missing heritability of HM and that ExGRS provides enhanced accuracy for HM prediction in Han Chinese ancestry, shedding new light on research and clinical practice.
Authors
- Yinghao Yao (ORCID: https://orcid.org/0009-0001-4763-0400)
- Ran Zhuo (ORCID: https://orcid.org/0000-0003-0546-5475)
- Liangde Xu (ORCID: https://orcid.org/0000-0003-0965-9955)
- Shilai Xing (ORCID: https://orcid.org/0000-0002-0869-1120)
- Jian Yuan (ORCID: https://orcid.org/0000-0002-1896-2561)
- Jianzhong Su (ORCID: https://orcid.org/0000-0003-1054-6042)
- Li‐Ya Qiao (ORCID: https://orcid.org/0000-0002-2336-0397)
- Zhen Ji Chen (ORCID: https://orcid.org/0000-0002-9782-2494)
- Zhengbo Xue
- Yunlong Ma (ORCID: https://orcid.org/0000-0002-1299-4802)
- Riyan Zhang
- Kai Li (ORCID: https://orcid.org/0009-0006-0254-9883)
- Yuhan Wang (ORCID: https://orcid.org/0000-0003-4447-5043)
- Hong Wang (ORCID: https://orcid.org/0000-0002-6192-3082)
- Hui Liu (ORCID: https://orcid.org/0000-0003-0444-5579)
- Haojun Sun
- Xiaoguang Yu (ORCID: https://orcid.org/0009-0008-2818-8531)
- Wei Dai (ORCID: https://orcid.org/0000-0001-7206-9347)
- Fan Lyu (ORCID: https://orcid.org/0000-0002-0878-5485)
- Jia Qu (ORCID: https://orcid.org/0000-0001-6360-2568)
- Ruowen Qiu
Institutions
- Beijing Tongren Hospital (CN)
- Wenzhou University (CN)
- Capital Medical University (CN)
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Zhejiang Lab (CN)
- University of Chinese Academy of Sciences (CN)
- University of Pennsylvania (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1038/s43856-024-00718-1
- Citations
- 6
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- National Natural Science Foundation of China