Polymorphism in Genes Encoding HSP40 Family Proteins is Associated with Ischemic Stroke Risk and Brain Infarct Size: A Pilot Study
We are the first to discover polymorphisms in genes encoding <i>HSP40</i> family proteins as a major risk factor for IS and its clinical manifestations. The comprehensive bioinformatics analysis revealed molecular mechanisms, underscoring their significance in the pathogenesis of IS, primarily reflecting the regulation of heat stress, proteostasis and cellular signalling.
Authors
- Ksenia Kobzeva (ORCID: https://orcid.org/0000-0002-0652-2219)
- Olga Y. Bushueva (ORCID: https://orcid.org/0000-0003-3333-0623)
- E. A. Patrakhanov (ORCID: https://orcid.org/0000-0002-8415-4562)
- Alexey Polonikov (ORCID: https://orcid.org/0000-0001-6280-247X)
- Denis E. Gurtovoy
- Vladimir M. Pokrovsky (ORCID: https://orcid.org/0000-0003-3138-2075)
Institutions
- Belgorod National Research University (RU)
- Kursk State Medical University (RU)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2024-12-04
- DOI
- https://doi.org/10.31083/j.jin2312211
- Citations
- 6
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Russian Science Foundation